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E2F4 (EP252), RMab

Presentation:

Price: $127.05

SKU:	BSB 2475
Antibody type:	Rabbit Monoclonal
Clone:	EP252
Isotype:	IgG
Concentrate Dilution:	1:50-1:200
Localization:	Nuclear
Tissue Control:	Tonsil, Placenta, Testis, Breast, Cervix, Colon
Species Reactivity:	Human

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Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

E2F4 is a transcritption factor protein that is encoded by the E2F4 gene on Chromosome 16.E2F4 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130. In quiescent cells, E2F4 is primarily localized in the nucleus but translocate to cytoplasm when the retinoblastoma family members are phosphorylated in response to mitogen.

E2F4 antibody is constitutively expressed throughout the cell. Squamous cell carcinomas of the salivary gland intense E2F4 staining, while most of the pleomorphic adenoma cells show nuclear reactivity of E2F4. Reduced expression of E2F4 has been reported in sporadic Burkitt lymphoma (sBL), and may play a role in Burkitt lymphoma tumorigenesis.

Presentation

E2F4 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Synonyms: E2F 4, E2F4, anti-E2F-4, anti E2F-4, anti-E2F 4, anti-E2F4, anti E2F 4, anti E2F4, E2F transcription factor 5 p130 binding, E2F 5

Specification Sheets

IVD - CE

Safety Data Sheets

SDS

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Option	SKU	Price
Presentation: 3 ml Predilute	BSB 2475	$127.05
Presentation: 7 ml Predilute	BSB 2476	$255.15
Presentation: 15 ml Predilute	BSB 2477	$511.35
Presentation: .1 ml Concentrate	BSB 2478	$147.00
Presentation: .5 ml Concentrate	BSB 2479	$383.25
Presentation: 1 ml Concentrate	BSB 2480	$765.45
Presentation: Control Slides [5]	BSB 2481	$67.00