ALK-1 / CD246 (RBT-ALK1), RMab
ALK-1 / CD246 (RBT-ALK1), RMab
Price:
$269.00
SKU:
BSB 5043
Antibody type:
Rabbit Monoclonal
Clone:
RBT-ALK1
Isotype:
IgG
Concentrate Dilution:
1:100-1:500
Localization:
Cytoplasmic, Nuclear
Tissue Control:
Anaplastic Large Cell Lymphoma
Species Reactivity:
Human
Sharing Discount has been applied
Description
Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Anaplastic Lymphoma Kinase (ALK) was originally discovered as a NPM (Nucleophosmin)-ALK fusion protein. The ALK gene is on chromosome 2. Upon translocation between chromosome 2 and chromosome 5 t(2;5), the ALK gene fuses with the NPM gene. The chimeric product (NPM ALK) resulting from t(2;5) translocation is a protein of 80 kDa with the N terminal portion of NPM linked to the complete intracellular portion of ALK.
ALK-1 antibody recognizes a human p80 protein, identified as a hybrid of the Anaplastic Lymphoma Kinase (ALK) gene and the Nucleophosmin (NPM) gene resulting from the t(2;5)(p23;q35) translocation found in a third of Large-Cell Lymphomas. ALK-1 is detected in 60% of Anaplastic Large-Cell Lymphomas and has proven to indicate a better prognosis in the ALK-1 (+) group.
Presentation
ALK-1 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: CD246, ALK, anti-ALK, anti ALK, ALK Receptor Tyrosine Kinase (RTK), anti-ALK Receptor Tyrosine Kinase (RTK), anti ALK Receptor Tyrosine Kinase (RTK), ALK RTK, type 1 receptor tyrosine kinase ALK, anti-CD246, anti CD246, anti-ALK RTK, anti ALK RTK, anti-type 1 receptor tyrosine kinase ALK, anti type 1 receptor tyrosine kinase ALK, anaplastic lymphoma receptor tyrosine kinase, NBLST3, alk-1, anti-alk-1, anti-alk1, alk1
Documentation
Specification Sheets
Safety Data Sheets
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Product Details
| Option | SKU | Price |
| Presentation: 3 ml Predilute | BSB 5043 | $269.00 |
| Presentation: 7 ml Predilute | BSB 5044 | $488.00 |
| Presentation: 15 ml Predilute | BSB 5045 | $881.00 |
| Presentation: .1 ml Concentrate | BSB 5046 | $301.00 |
| Presentation: .3 ml Concentrate | BSB 5047 | $662.00 |
| Presentation: 1 ml Concentrate | BSB 5048 | $1,012.00 |
| Presentation: Control Slides [5] | BSB-9010-CS | $181.00 |
