Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Alpha-synuclein is a 140 amino acids protein encoded by the SNCA gene. It is predominantly expressed in the neocortex, hippocampus, substantia nigra, thalamus, and cerebellum with smaller amounts are found in the heart, muscles, and other tissues. In the brain, alpha-synuclein is found mainly in presynaptic terminals.
An alpha synuclein fragment, known as the non-Abeta component (NAC) of Alzheimer’s disease amyloid, originally found in an amyloid-enriched fraction, was shown to be a fragment of its precursor protein, NACP. Alpha synuclein aggregates to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy. These disorders are known as synucleinopathies. Occasionally,
Lewy bodies contain tau protein; however, alpha synuclein and tau constitute two distinctive subsets of filaments in the same inclusion bodies.
Alpha synuclein pathology is also found in both sporadic and familial cases with Alzheimer’s disease. In rare cases of familial forms of Parkinson’s disease, there is a mutation in the gene coding for alpha-synuclein. Genomic duplication and triplication of the gene appear to be a rare cause of Parkinson’s disease in other lineages, although more common than point mutations. Hence certain mutations of alpha synuclein may cause it to form amyloid-like fibrils that contribute to Parkinson’s disease.
Presentation
Alpha Synuclein antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: SNCA, sc53955, α-synuclein, a-synuclein, a synuclein, alpha synuclein, alpha-synuclein, α synuclein, αsynuclein, anti alpha synuclein, anti SNCA, anti synuclein, anti α synuclein, anti α-synuclein, anti αsynuclein, anti-alpha synuclein, anti-SNCA, anti-synuclein, anti-α synuclein, anti-α-synuclein, anti-αsynuclein, synuclein, MGC110988, NACP, non A beta component of AD amyloid, Non A4 component of amyloid precursor, PARK1, PARK4, PD1, synuclein alpha non A4 component of amyloid precursor, synuclein alpha 140, ihc, anti-alpha synuclein
