Bax (E63), RMab
Price:
$218.00
SKU:
BSB 6078
Antibody type:
Rabbit Monoclonal
Clone:
E63
Isotype:
IgG
Concentrate Dilution:
1:50-1:200
Localization:
Cytoplasmic , Cell Membranous
Tissue Control:
Breast, Tonsil, Cervix, Hodgkin’s Lymphoma
Species Reactivity:
Human
Sharing Discount has been applied
Description
Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Bax is a protein of the bcl-2 gene family. It promotes apoptosis by competing with bcl-2 proper. The Bax gene contains a small promoter element that complements a binding domain on the multi-faceted p53 tumor suppressor. Wild-type p53 has been demonstrated to upregulate the transcription of a chimeric reporter plasmid, utilizing the consensus promoter sequence of Bax approx. 50-fold over mutant p53. Mutations in this consensus sequence eliminate transcription of the reporter gene. Thus, it is likely that p53 promotes Bax’s apoptotic faculties in vivo as a primary transcription factor.
Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Bax targets mitochondrial mem-branes, inducing mitochondrial damage and cell death in a caspase-independent manner. Bax antibody plays a critical role in the Bax-mediated apoptosis pathway by dimerizing with BclxL, causing the displacement of Bax. The displacement of Bax allows apoptosis to proceed.
Presentation
Bax is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: BAX, BCL2L4, sc7480, sc-7480, 7480, anti-Bax, anti Bax, anti BCL2 associated X, anti BCL2L4, anti-BCL2 associated X, anti-BCL2L4, BCL2 associated X, Dmelanogaster 1 1ogre gene for conceptual protein of 1 1ogre locus BAX, Dmelanogaster 1 1 ogre gene for conceptual protein of 1 1 ogre locus BAX, Apoptosis regulator BAX, bcl 2 like protein 4
Documentation
Specification Sheets
Safety Data Sheets
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Product Details
| Option | SKU | Price |
| Presentation: 3 ml Predilute | BSB 6078 | $218.00 |
| Presentation: 7 ml Predilute | BSB 6079 | $394.00 |
| Presentation: 15 ml Predilute | BSB 6080 | $710.00 |
| Presentation: .1 ml Concentrate | BSB 6081 | $242.00 |
| Presentation: .5 ml Concentrate | BSB 6082 | $533.00 |
| Presentation: 1 ml Concentrate | BSB 6083 | $812.00 |
| Presentation: Control Slides [5] | BSB-9026-CS | $101.00 |
