bcl-2 (BSB-5), MMab
Price:
$140.00
SKU:
BSB 5071
Antibody type:
Mouse Monoclonal
Clone:
BSB-5
Isotype:
IgG1/K
Concentrate Dilution:
1:50-1:200
Localization:
Cytoplasmic, Membranous
Tissue Control:
Tonsil, Lymph Node, Breast, Bone Marrow
Species Reactivity:
Human
Sharing Discount has been applied
Description
Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
bcl-2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of bcl-2, such as in the case of translocation of bcl-2 to Ig heavy-chain loci, is thought to be the cause of Follicular Lymphoma.
The bcl-2 antibody has shown consistent negative reaction on reactive germinal centers and positive staining of neoplastic follicles in Follicular Lymphoma. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. This antibody may also be used in distinguishing between those Follicular Lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2-negative. The bcl-2 antibody has been used as a predictive biomarker for recurrence of Cancer of the Breast and Non-Small-Cell Carcinoma of the Lung.
Presentation
bcl-2 antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: bcl2, anti-bcl2, antibcl2, anti-bcl-2, anti-bcl2, Bcl 2, PPP1R50, Bcl2, sc509, sc-509, 509, anti-Bcl-2, anti Bcl-2, anti-BCL2, anti BCL2, anti-Bcl 2, anti Bcl 2, anti PPP1R50, anti-PPP1R50, Apoptosis regulator Bcl 2, B cell CLL lymphoma 2, protein phosphatase 1 regulatory subunit 50
Documentation
Specification Sheets
Safety Data Sheets
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Product Details
| Option | SKU | Price |
| Presentation: 3 ml Predilute | BSB 5071 | $140.00 |
| Presentation: 7 ml Predilute | BSB 5072 | $175.00 |
| Presentation: 15 ml Predilute | BSB 5073 | $339.00 |
| Presentation: .1 ml Concentrate | BSB 5074 | $133.00 |
| Presentation: .5 ml Concentrate | BSB 5075 | $255.00 |
| Presentation: 1 ml Concentrate | BSB 5076 | $344.00 |
| Presentation: Control Slides [5] | BSB-9029-CS | $101.00 |
