Beta-Catenin (14), MMab
                    
                    
                    
                        
                        
				
                            
					
    
            
						
                
            
					
            
						
                
            
					
        
    
				 
                        
			 
                        
                        
				
                            Price:
                            $142.00
                        
			
                        
                     
                    
                    
                    
                    
				
                        SKU:
                        BSB 5085
                    
			
                    
        
				
            Antibody type:
            Mouse Monoclonal
        
			
    
        
				
            Clone:
            14
        
			
    
        
				
            Isotype:
            IgG1
        
			
    
        
				
            Concentrate Dilution:
            1:50-1:200
        
			
    
        
				
            Localization:
            Cytoplasmic, Membranous, Nuclear
        
			
    
        
				
            Tissue Control:
            Fibromatosis - Breast Ca/Abdomen
        
			
    
        
				
            Species Reactivity:
            Human, Dog, Mouse, Rat, Chicken
        
			
    
                    
				
    
					
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        Description
        
						
            Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Beta-Catenin is a subunit of the Cadherin protein complex. Cadherins are a type of protein normally expressed on the surface of certain cells. Specifi cally, Beta Cateinin is a 92 kDa protein normally found in the cytoplasm of the cell in the sub-membranous location. The Beta-Catenin antibody is associated with E-Cadherin and may be essential for the function of E-Cadherin.
Mutations in the Beta-Catenin gene result in the nuclear accumulation of this protein. Nuclear accumulation of this protein has been demonstrated in Fibromatosis lesions of the breast and abdomen, and therefore is useful in differentiating this lesion from other spindle-cell lesions that may occur in these locations.
Presentation
Beta-Catenin antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: CTNNB1, sc7963, β-catenin, b-catenin, b catenin, beta catenin, beta-catenin, sc-7963, 7963, β catenin, βcatenin, anti-β-catenin, anti β-catenin, anti-β catenin, anti-βcatenin, anti β catenin, anti βcatenin, anti beta-Catenin, anti CTNNB1, anti-beta-Catenin, anti-CTNNB1, catenin cadherin associated protein beta 1 88kDa, catenin beta 1, CTNNB, DKFZp686D02253, FLJ25606, FLJ37923, betacatenin, bcatenin, catenins, PRO2286
 
    
				 
    
					
        Documentation
        
						Specification Sheets
Safety Data Sheets
					 
    
				 
    
    
					
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											| Option | SKU | Price | 
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											| Presentation: 7 ml Predilute | BSB 5086 | $358.00 | 
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											| Presentation: Control Slides [5] | BSB-9033 | $67.00 |