Intended Use
For In Vitro Diagnostic Use.
This antibody is intended for use in Immunohistochemical (IHC) and Immunofluorescence (IF) applications on formalin-fixed paraffin-embedded tissues (FFPE), frozen tissue sections and cell preperations. Interpretation of results should be perfomed by a qualified medical professional.
Summary and Explanation
Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen(HLA) system. It serves several critical functions in immunity, tolerance, and autoimmunity with the other numerous components.
Low serum complement activity or low protein concentrations of complement C4 are found on Systemic Lupus Erythematosus (SLE) and it is often associated with Congenital C4 deficiency. Complete deficiencies of complement components are among the strongest genetic risk factors for SLE or lupus-like disease, across HLA haplotypes and racial backgrounds.
Presentation
C4c is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: anti-c4c, anti c4c, antic4c, complement, component 4, anti-c4