Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
LI-Cadherin, also known as Cadherin-17, is part of the cadherin superfamily and is a calcium-dependent, membrane-associated glycoprotein. Cadherins are responsible for mediating cell-cell adhesion and are important for the structural integrity of epithelia. LI-Cadherin consists of an extracellular region containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. It is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. It may play a role in the morphological organization of liver and intestine.
In normal tissues, the LI-Cadherin antibody labels epithelial cells in the gastrointestinal tract and pancreatic duct, but not in kidney, liver and other tissues. In tumors, LI-Cadherin is expressed on adenocarcinoma of the digestive system, including liver cancer. It is a sensitve marker for the identification of gastric intestinal metaplasia and well differentiated adenocarcinomas.
Presentation
LI-Cadherin antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: CDH16, HPT1, sc393533, LI cadherin, LIcadherin, CDH17, anti CDH16, anti CDH17, anti HPT1, anti LI cadherin, anti LI-cadherin, anti LIcadherin, anti-CDH16, anti-CDH17, anti-HPT1, anti-LI cadherin, anti-LI-cadherin, anti-LIcadherin, cadherin 17 LI cadherin liver intestine, HPT 1, cadherin 17, cadherin-17, anti-cadherin 17, anti-cadherin-17, cad 17, cad-17, anti-cad 17, anti-cad17
