Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calicification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization.
Carbonic Anhydrase 9 (CA9) is a transmembrane protein and the only tumor-associated CA isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be invovled in cell proliferation and transformation. Carbonic Anhydrase 9 is considered to be one of the best cellular biomarkers of hypoxic regions in many solid regions.
Presentation
Carbonic Anhydrase 9 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: anti-ca9, anti-carbonic anhydrase 9, CA9, sc365900, sc-365900, 365900, CA IX, CAIX, carbonate dehydratase IX, carbonic anhydrase 9, Carbonic anhydrase IX, carbonic dehydratase, membrane antigen MN, MN, P54 58N, pMW1, RCC associated antigen G250, RCC associated protein G250, Renal cell carcinoma associated antigen G250
