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Cathepsin K (BSB-172), MMab

CTSK, anti-cathepsin K, anti cathepsin K, anti-CTSK, anti CTSK, cathepsin K, cathepsin X MAIN

Cathepsin K (BSB-172), MMab

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Price: $225.00

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SKU: BSB-3800-3

Antibody type: Mouse Monoclonal

Clone: BSB-172

Isotype: IgG1, kappa

Concentrate Dilution: 1:25-1:100

Localization: Cytoplasmic

Tissue Control: Breast, Liver

Species Reactivity: Human

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Description

Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Cathepsin K is a cysteine protease, which may be secreted as a pro-enzyme and is activated in a low-pH environment such as lysosomes. Cathepsin K accepts Arg and Lys residues at the P1 active site, acting on Proteolytically Activated Receptors (PARs) in extracellular matrix. Cathepsin K also cleaves collagen and degrades bone matrix, and is involved in the mTOR signaling pathway of cellular autophagy and apoptosis. Cathepsin K has also been shown to play a role in MHC II antigen presentation, keratinocyte differentiation, platelet aggregation, and in the Hedgehog signaling pathway.

As a protease active in the extracellular matrix and lysosomes, Cathepsin K has been implicated in cancer progression and invasiveness. Cathepsin K has been shown to have specific proteolytic activity on PAR-3 and PAR-4, which are expressed in the EMC of epithelial-mesenchymal cells in breast cancer. Proteolytic cleavage of PARs stimulates platelet aggregation and p38 phosphorylation in the MAPK pathway.

Cathepsin K-induced proteolytic cleavage induces upregulation of proteins related to metastasis in bone and prostate cancer, and epithelial-mesenchymal-like cells in breast cancer.

Synonyms: CTSK, anti-cathepsin K, anti cathepsin K, anti-CTSK, anti CTSK, cathepsin K, cathepsin O, cathepsin O1, Cathepsin O2, cathepsin X

Documentation

Specification Sheets

IVD - CE

Safety Data Sheets

SDS

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Product Details

Option	SKU	Price
Presentation: 3 ml Predilute	BSB-3800-3	$225.00
Presentation: 7 ml Predilute	BSB-3800-7	$337.00
Presentation: 15 ml Predilute	BSB-3800-15	$564.00
Presentation: .1 ml Concentrate	BSB-3800-01	$225.00
Presentation: .5 ml Concentrate	BSB-3800-05	$451.00
Presentation: 1 ml Concentrate	BSB-3800-1	$788.00
Presentation: Control Slides [5]	BSB-9438-CS	$101.00

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