Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
CD123 is α chain of the IL-3 receptor. This 60-70 kDa transmembrane protein, by itself, binds to IL-3 with rather low affinity. However, when associated with CD131 (common β chain), the protein binds to IL-3 with high affinity. The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes. The receptor belongs to the Type I cytokine-receptor family and is a heterodimer with a unique alpha chain paired with the common beta (beta c or CDw131) subunit.
The CD123 receptor, found on pluripotent progenitor cells, induces tyrosine phosphorylation within the cell and promotes proliferation and differentiation within the hematopoietic cell lines. CD123 is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, and megakaryocytes.
Presentation
CD123 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: IL3RA, IL-3Rα, IL-3Ralpha, IL-3R alpha, IL-3Ra, IL-3R a, 80650, IL 3Rα, IL3Rα, CD123, CD123 antigen, hIL 3Ra, IL 3R alpha, IL3R, IL3RAY, IL3RX, IL3RY, interleukin 3 receptor alpha low affinity, interleukin 3 receptor subunit alpha, MGC34174, IL 3 receptor subunit alpha, IL 3R subunit alpha, IL 3RA, IL 3 receptor alpha SP2 isoform, anti-cd123, anticd123, anti-cd123, anti cd123, anti-il-3ra, anti il3ra
