Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
D147 is a transmembrane glycoprotein also known as Basigin or EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), participating in tumor development and viral entry pathways. CD147 is a member of the immunoglobulin superfamily, upregulated in asthmatic, diabetic, and other inflammatory pathways where it induces expression of Matrix Metalloproteinase 1 and 9. CD147 and its effectors are induced by high-glucose concentration in monocytes and promote their migration. CD147 also participates in fibroblast differentiation through TGF-b1-induced signaling pathways, and is a marker of undifferentiated human embryonic stem cells.
CD147 antibody has been found to be upregulated in cancer stem cells, resulting in increased metabolism through lactic acid export, increased production of hyaluronan, inhibiting apoptosis, and acting as a main upstream stimulator of matrix metalloproteinases. In clinical studies, CD147 has been associated with larger tumors, deeper invasion, and more lymphocytes. CD147 also facilitates the entry of malaria parasite Plasmodium falciparum into red blood cells, and the entry of coronaviruses into human cells by binding the spike glycoprotein, functioning as the second receptor for SARS-CoV-2 and potential participant in pulmonary fibrosis.
Presentation
CD147 antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: cd147, cd-147 cd 147, anti-cd147, anti-cd-147, cd147 antibody, anti-cd147 antibody, sars-cov-2 receptors, sars cov-2 receptors, covid-19 receptors, sars-cov-2 antibodies sars-cov-2 ihc, sars-cov-2 immunohistochemistry
