CD15 (BSB-119), MMab

Intended Use

For In Vitro Diagnostic Use

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CD15 is a phosphatidylinositol-anchored transmembrane protein found on neutrophils and which may be involved in phagocytosis. It is expressed in patients with Hodgkin’s Disease, some B-cell Chronic Lymphocytic Leukemias, Acute Lymphoblastic Leukemias, and most Acute Non-Lymphocytic Leukemias. It is also called Lewis x.

A positive reaction for CD15 antibody combined with a negative reaction for CD45 and other B and T-lineage markers provides support for Reed-Sternberg cells found in Hodgkin’s disease. Also, this antibody does not detect Mesotheliomas, making it a more frequently used antibody to distinguish Epithelial Mesothelioma from Adenocarcinoma.