CD3 (RBT-CD3), RMab
Price:
$167.00
SKU:
BSB 6422
Antibody type:
Rabbit Monoclonal
Clone:
RBT-CD3
Isotype:
IgG
Concentrate Dilution:
1:50-1:200
Localization:
Membranous
Tissue Control:
Tonsil, Lymph Node, Liver, Testis, Kidney, Colon
Species Reactivity:
Human
Sharing Discount has been applied
Description
Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
The CD3 antigen is a protein complex composed of three distinct chains (CD3γ, CD3δ and CD3ε) that associate with T-cell receptors and the ζ-chain to generate an activation signal in T-lymphocytes. The TCR, ζ-chain and CD3 molecules together comprise the TCR complex. The CD3γ, CD3δ and CD3ε chains are highly-related cell surface proteins of the immunoglobulin superfamily containing a single extracellular immunoglobulin domain. The intracellular tails of the CD3 molecules contain a single conserved motif known as an immunoreceptor tyrosine-based activation motif (or ITAM for short), which is essential for the signaling capacity of the TCR. Phosphorylation of the ITAM on CD3 renders the CD3 chain capable of binding the enzyme ZAP70 (zeta-associated protein), a kinase important in the signaling cascade of the T-cell.
The CD3 antibody has been considered the best all-around T-cell marker. This antibody reacts with an antigen present in early thymocytes. The positive staining of this marker may represent a sign of early commitment to the T-cell lineage.
Presentation
CD3 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: cd-3 anti cd3, anti-cd3, anti cd-3, anti-cd-3, anti-CD3E, anti CD3E, CD3 antigen, CD3 monoclonal, anti-CD3 antigen, anti CD3 antigen, anti-CD3 monoclonal, anti CD3 monoclonal, CD3 epsilon, CD3e antigen epsilon polypeptide TiT3 complex, CD3e molecule epsilon CD3 TCR complex, FLJ18683, T cell antigen receptor complex epsilon subunit of T3, T cell surface antigen T3 Leu 4 epsilon chain, T cell surface glycoprotein CD3 epsilon chain, T3E, TCRE
Documentation
Specification Sheets
Safety Data Sheets
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Product Details
| Option | SKU | Price |
| Presentation: 3 ml Predilute | BSB 6422 | $167.00 |
| Presentation: 7 ml Predilute | BSB 6423 | $305.00 |
| Presentation: 15 ml Predilute | BSB 6424 | $542.00 |
| Presentation: .1 ml Concentrate | BSB 6425 | $275.00 |
| Presentation: .5 ml Concentrate | BSB 6426 | $548.00 |
| Presentation: 1 ml Concentrate | BSB 6427 | $929.00 |
| Presentation: Control Slides [5] | BSB-9082-CS | $101.00 |
