Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
CD4 is a glycoprotein expressed on the surface of T-helper cells, regulatory T-cells, monocytes, macrophages, and dendritic cells. On T-cells, CD4 is the co-receptor for the T-cell receptor (TCR). It amplifies the signal gener-ated by the TCR by recruiting the tyrosine kinase that is essential for activating many molecules involved in the signaling cascade of an activated T-cell.
CD4 antibody expression is involved in the recognition of Type II Major Histocompatability Complex antigens (MHC-II). CD4 is also the receptor for Human Immunodeficiency Virus (HIV). It is present on most T-helper cells and normal thymocytes.
Presentation
CD4 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: CD4, CD4 molecule, anti-CD4, anti CD4, anti-CD4 molecule, anti CD4 molecule, cluster of differentiation CD4, anti-cluster of differentiation CD4, anti cluster of differentiation CD4, CD4 antigen p55, CD4 receptor, CD4mut, T cell surface antigen T4 Leu 3, T cell surface glycoprotein CD4