Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
The CD45 antigen is a protein which was originally called Leukocyte Common Antigen. It is a Type I transmembrane protein which is in various forms present on all differentiated hematopoietic cells except erythrocytes and assists in the activation of those cells (a form of co-stimulation). It is expressed in Lymphomas, B-cell Chronic Lymphocytic Leukemia, Hairy Cell Leukemia, and Acute Non-lymphocytic Leukemia.
CD45 antibody routinely used to aid in the differential diagnosis of undifferentiated neoplasms, whenever malignant Lymphoma is suspected by the morphological or clinical data. It is a highly specific antibody; thus, a positive result is highly indicative of lymphoid or myeloid origin. Certain types of lymphoid neoplasms may lack CD45 (Hodgkin’s Disease, some T-cell Lymphomas and some Leukemias) so its absence does not rule out a hematolymphoid tumor. This antibody is exclusively expressed by cells of hematopoietic lineage and is present in most benign and malignant lymphocytes, erythrocytes and plasma cell precursors.
Presentation
CD45 antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: protein tyrosine phosphatase receptor type C, PTPRC, sc1187, sc-1187, 1187, anti-CD45, anti CD45, anti-PTPRC, anti PTPRC, anti-protein tyrosine phosphatase receptor type C, anti protein tyrosine phosphatase receptor type C, B220, CD45, CD45 antigen, CD45R, GP180, L CA, LCA, Leukocyte common antigen, LY5, protein tyrosine phosphatase receptor type c polypeptide, T200, T200 glycoprotein, T200 leukocyte common antigen, receptor type tyrosine protein phosphatase C
