Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
CD45R contains an extracellular domain, a single transmembrane segment and two tandem intracyto-plasmic catalytic domains. It is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T and B-cell antigen-receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen-receptor signaling. CD45R also suppresses JAK kinases, and thus functions as a regulator of cytokine-receptor signaling.
CD45R antibody represents a restricted form of the CD45 family, which primarily recognizes only cells of B lineage from proB-cell through mature B lymphocytes and, prior to the availability of anti-CD19 MAbs, was commonly used as a pan B-cell marker. It also reacts with certain activated T-cells, as well as non-MHC restricted lytically active lymphokine-activated killer (LAK) cells. MB1 antibody stains preferentially B-cells and their neoplasms but is less specific, as it will also react with some T-cell Lymphomas and Non-lymphoid Tumors. The antigen for this antibody is in the membrane of all B-cells with the exception of plasma cells and some mature T-cells.
Presentation
CD45R antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: Cd45, protein tyrosine phosphatase receptor type C, Ptprc, sc19597, sc-19597, 19597, anti-CD45R, anti CD45R, anti-CD45, anti CD45, anti-PTPRC, anti PTPRC, anti-protein tyrosine phosphatase receptor type C, anti protein tyrosine phosphatase receptor type C, Leukocyte common antigen precursor, L CA, Ly 5, B220, CD45R, Leukocyte common antigen, loc, Lymphocyte antigen 5, lymphocyte common antigen, Lyt 4, T200, receptor type tyrosine protein phosphatase C
