Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
The CD45 family consists of multiple members that are all products of a single complex gene. Three isoforms of CD45 exist: on B-lymphocytes, where the protein is called B220 (its molecular mass is 220 kDA); on naive T-lymphocytes, where it is called CD45 RA, and on activated and memory T-lymphocytes, where it is called CD45 RO. CD45RO is a single-chain, transmembraneous glycoprotein which represents the low molecular weight isoform of the Leukocyte Common Antigen (LCA). It is expressed on most thymocytes, about 45% of peripheral blood T-cells, virtually all T-cells in skin reactive infiltrates, and the majority of T-cell malignancies. It is also found on a subset of B-cells and on exceptional B-cell Lymphomas.
CD45RO Antibody (T-Cell, Pan) reacts with thymocytes and activated T-cells, but only on a subpopulation of resting T-cells. This antibody shows no reactivity with B-cells, making it a good marker for T-cell tumors to be phenotyped. In addition, granulocytes and monocytes are also labeled with this antibody. T-Cell, Pan has been designated as CD45RO at The International Leukocyte Typing Workshop.
Presentation
CD45RO antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: CD45, PTPRC, protein tyrosine phosphatase receptor type C, sc1183, sc-1183, 1183, anti-CD45RO, anti CD45RO, anti-CD45, anti CD45, anti-PTPRC, anti PTPRC, anti-protein tyrosine phosphatase receptor type C, anti protein tyrosine phosphatase receptor type C, Leukocyte common antigen precursor, L CA, Lymphocyte antigen 5, Ly 5, T200, CD45 antigen, B220, CD45R, Lyt 4, loc, GP180, LCA, Leukocyte common antigen, LY5, protein tyrosine phosphatase receptor type c polypeptide, T200 glycoprotein, T200 leukocyte common antigen, receptor type tyrosine protein phosphatase C
