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CITED1 (BSB-177), MMAb

anti-cited1, anti cited1, CITED1, anti-msg1, anti msg1, melanocyte specific gene 1, melanocyte specific protein 1, MSG1 MAIN

CITED1 (BSB-177), MMAb

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Price: $225.00

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SKU: BSB-3808-3

Antibody type: Mouse Monoclonal

Clone: BSB-177

Isotype: IgG2a, Kappa

Concentrate Dilution: 1:25-1:100

Localization: Cytoplasmic, Nuclear

Tissue Control: Testis, Renal tubules

Species Reactivity: Human

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Description

Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

CITED1 is a transcriptional coactivator of the p300/CBP-mediated transcription complex. It enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. It also stimulates estrogen-dependent transactivation activity mediated by estrogen receptor signaling by stabilizing the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. CITED1 also positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex, and associates with chromatin to the estrogen-responsive TGF-alpha promoter region in an estrogen-dependent manner.

Additionally, CITED1 induces transcription from estrogen-responsive promoters and protection against cell death in breast cancer, potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter, and acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. Current investigations suggest that it may have a role in pigmentation of melanocytes.

Synonyms: anti-cited1, anti cited1, CITED1, anti-msg1, anti msg1, melanocyte specific gene 1, melanocyte specific protein 1, MSG1

Documentation

Specification Sheets

IVD - CE

Safety Data Sheets

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Product Details

Option	SKU	Price
Presentation: 3 ml Predilute	BSB-3808-3	$225.00
Presentation: 7 ml Predilute	BSB-3808-7	$337.00
Presentation: 15 ml Predilute	BSB-3808-15	$564.00
Presentation: .1 ml Concentrate	BSB-3808-01	$225.00
Presentation: .5 ml Concentrate	BSB-3808-05	$451.00
Presentation: 1 ml Concentrate	BSB-3808-1	$788.00
Presentation: Control Slides [5]	BSB-9446-CS	$101.00

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