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Claudin-4 (EP417), RMab

claudin 4, claudin-4, CLDN4, claudin4, anti-claudin-4, anti claudin-4, anti-claudin 4 MAIN

Claudin-4 (EP417), RMab

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Price: $264.00

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SKU: BSB-3792-3

Antibody type: Rabbit Monoclonal

Clone: EP417

Isotype: IgG

Concentrate Dilution: 1:50-1:200

Localization: Membranous

Tissue Control: Thyroid, Placenta, Kidney, Colon, Breast, Tonsil

Species Reactivity: Human

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Description

Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Claudin-4 belongs to the tight-junction-associated protein group. The expression of Claudin-4 is found in most epithelial cells, but not in Mesothelial cells.

Detection of Claudin-4 via IHC allows distinguishing Lung Adenocarcinoma from malignant Mesothelioma in tissue samples. In malignant effusions, Claudin-4 detection effectively identifies Adenocarcinoma from malignant Mesothelioma with high sensitivity and specificity. Another study showed that Claudin-4 detection is an independent positive prognostic factor for Gastric Carcinoma, which restricts the migration of gastric cancer cells. Claudin-4 overexpression in gastric cancer cells is associated with epigenetic derepression and contributes to the suppression of gastric cancer progression and positive prognosis of the patient. On the other hand, Claudin-4 expression is downregulated in epithelial malignancies and in precancerous lesions. In addition, Claudin-4 plays an important role in tumor cell invasion and metastasis. Claudin-4 is a highly specific and sensitive marker to differentiate epithelioid mesotheliomas from metastatic carcinomas.

Synonyms: claudin 4, claudin-4, CLDN4, claudin4, anti-claudin-4, anti claudin-4, anti-claudin 4

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Product Details

Option	SKU	Price
Presentation: 3 ml Predilute	BSB-3792-3	$264.00
Presentation: 7 ml Predilute	BSB-3792-7	$396.00
Presentation: 15 ml Predilute	BSB-3792-15	$663.00
Presentation: .1 ml Concentrate	BSB-3792-01	$264.00
Presentation: .5 ml Concentrate	BSB-3792-05	$531.00
Presentation: 1 ml Concentrate	BSB-3792-1	$928.00
Presentation: Control Slides [5]	BSB-9432-CS	$101.00

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