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Claudin-7 (EP399), RMab

Claudin-7, claudin 7, cldn7, cldn-7, anti-claudin-7, anti-claudin 7, anti-cldn7, anti-cldn-7 MAIN

Claudin-7 (EP399), RMab

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Price: $259.00

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SKU: BSB-3719-3

Antibody type: Rabbit Monoclonal

Clone: EP399

Isotype: IgG

Concentrate Dilution: 1:50-1:200

Localization: Cytoplasmic, Membranous, Nuclear

Tissue Control: Breast, Colon, Fallopian Tubem Pancreas

Species Reactivity: Human

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Description

Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Claudin-7 is encoded by the CLDN7 gene and is a member of the claudin family. Claudin-7 is a component of tight junctions and plays important roles in maintaining cell polarity and tightly connecting the barriers between cells. Abnormal Claudin-7 protein expression is closely related to tumor occurrence, development, and metastasis. Claudin-7 expression is down-regulated in Colorectal Cancer (CRC) and Lung Cancer tissues and loss of Claudin-7 is associated with the degree of cancer cell differentiation and metastasis.

Claudin-7 may serve as a tumor suppressor, as it is involved in pathways of cell proliferation and epithelial barrier formation through Integrin signaling networks. The deficient extracellular matrix in cells with low Claudin-7 antibody expression promotes abnormal growth patterns and metastasis in Ductal and Lobular Breast Carcinomas, and Claudin-7 expression is lost in ~50% of primary tumors in Breast Cancers. While Claudin-7 downregulation was found in Esophageal, Head/Neck, and Prostate Cancers, overexpression of Claudin-7 is found in many Ovarian Cancers and may also lead to increased tumor invasiveness.

Synonyms: claudin-7, claudin 7, cldn7, cldn-7, anti-claudin-7, anti-claudin 7, anti-cldn7, anti-cldn-7

Documentation

Specification Sheets

IVD

Safety Data Sheets

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Product Details

Option	SKU	Price
Presentation: 3 ml Predilute	BSB-3719-3	$259.00
Presentation: 7 ml Predilute	BSB-3719-7	$464.00
Presentation: 15 ml Predilute	BSB-3719-15	$816.00
Presentation: .1 ml Concentrate	BSB-3719-01	$269.00
Presentation: .5 ml Concentrate	BSB-3719-05	$585.00
Presentation: 1 ml Concentrate	BSB-3719-1	$928.00
Presentation: Control Slides [5]	BSB-9121-CS	$101.00

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