DDR1 (BSB-173), MMab

Summary and Explanation

Increased expression of DDR1 has been documented in several types of cancer and fibrotic conditions including skin hypertrophic scars, Idiopathic Pulmonary Fibrosis, cirrhotic liver and renal fibrosis. DDR1 was identified as one of the 72 genes that were significantly upregulated in malignant versus benign Pancreatic Cancer, and high levels of DDR1 mRNA were found in Hepatocellular Carcinomas, which significantly correlated with advanced tumor stage. Overexpression of DDR1 in Lung Cancer cells resulted in a significant increase of cell motility and invasiveness, therefore, poor prognosis for the patients. Dysregulation of DDR1 can cause changes in the ECM that impede drug delivery to tumors, and under-expression of DDR1 is correlated with tissue and organ atrophy.

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Synonyms: CD167, DDR1, discoidin domain receptor tyrosine kinase 1, anti-DDR1, anti DDR1, TRK E, TRKE, Tyrosine kinase DDR