Desmoglein-3 (EP306), RMab
Desmoglein-3 (EP306), RMab
Price:
$291.00
SKU:
BSB 2894
Antibody type:
Rabbit Monoclonal
Clone:
EP306
Isotype:
IgG
Concentrate Dilution:
1:50-1:200
Localization:
Cytoplasmic, Membranous
Tissue Control:
Tonsil, Skin, Cervix, Cervical Carcinoma
Species Reactivity:
Human
Sharing Discount has been applied
Description
Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Desmoglein-3 is a protein that is encoded by the DSG3 gene on Chromosome 18. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component ofdesmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.
The Desmoglein-3 antibody has been cited as a superior marker for Lung Squamous Cell Carcinomas, and helps distinguish lung squamous cell carcinoma cases from lung adenocarcinoma. Studies have also shown that a panel consisiting of Desmoglein-3 utilized with Napsin A can be a useful Immunohistochemical marker for differentiation of lung squamous cell carcinoma and adenocarcinoma from other subtypes. Lung cases that are typically positive for Desmoglein 3 tend to have a poor clinical outcome.
Presentation
Desmoglein-3 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: desmoglein-3, dsg, CDHF6, DSG3, anti-dsg3, anti dsg3, Desmoglein 3, Pemphigus Vulgaris Antigen (PVA), anti-CDHF6, anti CDHF6, anti-Desmoglein 3, anti Desmoglein 3, anti-Pemphigus Vulgaris Antigen (PVA), anti Pemphigus Vulgaris Antigen (PVA), desmoglein 3 pemphigus vulgaris antigen, PVA
Documentation
Specification Sheets
Safety Data Sheets
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Product Details
| Option | SKU | Price |
| Presentation: 3 ml Predilute | BSB 2894 | $291.00 |
| Presentation: 7 ml Predilute | BSB 2895 | $439.00 |
| Presentation: 15 ml Predilute | BSB 2896 | $732.00 |
| Presentation: .1 ml Concentrate | BSB 2897 | $291.00 |
| Presentation: .5 ml Concentrate | BSB 2898 | $587.00 |
| Presentation: 1 ml Concentrate | BSB 2899 | $1,024.00 |
| Presentation: Control Slides [5] | BSB-9162-CS | $101.00 |
