DOG-1 (RBT-DOG1), RMab
Price:
$210.00
SKU:
BSB 6268
Antibody type:
Rabbit Monoclonal
Clone:
RBT-DOG1
Isotype:
IgG
Concentrate Dilution:
1:100-1:500
Localization:
Cytoplasmic, Membranous
Tissue Control:
Salivary Gland, Breast, GIST
Species Reactivity:
Human
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Description
Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
DOG1 (discovered on GIST 1), a cell-surface protein of unknown function, is expressed strongly on the cell surface of GISTs and is rarely expressed in other soft tissue tumors. Among GIST cases with c-Kit mutations, the DOG1 antibody identified 11% more cases than a c-Kit antibody.
DOG1 antibody identifies the vast majority of both c-Kit negative and PDGFRA mutated GIST cases that may still benefit from imatinib mesylate (Gleevac), an inhibitor of the kit tyrosine kinase. In addition, DOG1 immunoreactivity is seen in fewer cases of mesenchymal and epithelial tumors, and melanomas when compared with c-Kit. The use of this highly-sensitive and specific novel marker should increase the accuracy of GIST diagnosis.
Presentation
DOG-1 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: dog1, dog-1, anti-dog1, anti-dog-1, anti dog1, anti dog-1, discovered on gist 1
Documentation
Specification Sheets
Safety Data Sheets
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Product Details
| Option | SKU | Price |
| Presentation: 3 ml Predilute | BSB 6268 | $210.00 |
| Presentation: 7 ml Predilute | BSB 6269 | $380.00 |
| Presentation: 15 ml Predilute | BSB 6270 | $683.00 |
| Presentation: .1 ml Concentrate | BSB 6271 | $242.00 |
| Presentation: .5 ml Concentrate | BSB 6272 | $592.00 |
| Presentation: 1 ml Concentrate | BSB 6273 | $860.00 |
| Presentation: Control Slides [5] | BSB-9163-CS | $101.00 |
