ERCC1 (EP219), RMab
Price:
$199.00
SKU:
BSB 2482
Antibody type:
Rabbit Monoclonal
Clone:
EP219
Isotype:
IgG
Concentrate Dilution:
1:50-1:200
Localization:
Nuclear
Tissue Control:
Tonsil, Testis, Breast, Prostate
Species Reactivity:
Human, Predicted: Mouse
Sharing Discount has been applied
Description
Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
DNA excision repair protein ERCC1 is encoded by the ERCC1 gene on chromosome 19.Excision Repair Cross Complementing 1 (ERCC1) is a mammalian nucleotide excision repair (NER) enzyme involved in repair of damaged DNA. ERCC1 is a homologous to RAD10 in Saccharomyces cerevisiae, which is required in mitotic intrachromosomal recombination and repair.
ERCC1 is required in repair of cisplatin-induced DNA adducts and ultraviolet (UV)-induced DNA damage. High expression of ERCC1 antibody has been linked to tumor progression in a variety of cancers including non-small cell lung cancer (NSCLC), squamous cell carcinoma of the head, ovarian cancer and esophageal cancer.Increased levels of ERCC1 expression may correlate with a lower response to platinum based chemotherapies. Studies have also showed however, that In non-small cell lung carcinoma (NSCLC), surgically removed tumors that receive no further therapy have a better survival if ERCC1-positive than if ERCC1-negative.
Presentation
ERCC1 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, fi lter sterilized and diluted in buff er pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: ERCC1, anti-ERCC1, anti ERCC1, DNA polymerase eta, Polh, polymerase DNA directed eta RAD 30 related, RAD30 homolog A, RAD30A, Xeroderma pigmentosum variant type protein homolog, XPV, DNA directed DNA polymerase eta
Documentation
Specification Sheets
Safety Data Sheets
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Product Details
| Option | SKU | Price |
| Presentation: 3 ml Predilute | BSB 2482 | $199.00 |
| Presentation: 7 ml Predilute | BSB 2483 | $307.00 |
| Presentation: 15 ml Predilute | BSB 2484 | $615.00 |
| Presentation: .1 ml Concentrate | BSB 2485 | $176.00 |
| Presentation: .5 ml Concentrate | BSB 2486 | $399.00 |
| Presentation: 1 ml Concentrate | BSB 2487 | $639.00 |
| Presentation: Control Slides [5] | BSB-9171-CS | $101.00 |
