GAB1 (BSB-155), MMab
Price:
$217.00
SKU:
BSB-3727-3
Antibody type:
Mouse Monoclonal
Clone:
BSB-155
Isotype:
IgG2a
Concentrate Dilution:
1:25-1:100
Localization:
Cytoplasmic, Membranous
Tissue Control:
Breast, Prostate, Testis, Tonsil, Stomach
Species Reactivity:
Human, Mouse, Rat
Sharing Discount has been applied
Description
Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
GRB2-associated-binding protein 1 (GAB1) is encoded by the GAB1 gene. GAB1 is a member of the IRS1-like multisubstrate docking protein family that transduces signals from various tyrosine kinases, such as Met, FGFR1, and EGFR. GAB1 plays a central role in cellular growth response, transformation, and apoptosis, as well as inflammatory responses. GAB1 is involved in the amplification of IL-6- induced MAPK pathway and promotes inflammation.
Somatic mutations of the GAB1 gene have been detected in Breast and Colorectal Cancers and studies have shown that elevated expressions of GAB1 antibody have been associated with Breast Cancer metastasis by dissociating the polarity-associated partitioning defective (PAR) complex and promoting epithelial-to-mesenchymal transition. Upregulation of GAB1 is an indication of unfavorable prognosis for Hepatocellular Carcinoma and Epithelial Ovarian Cancer. GAB1 overexpression has also been seen in Adult Acute Lymphoblastic Leukemia and Medulloblastomas. GAB1 antibody can be used with a panel of immunohistochemical markers in the classification of Medulloblastomas into SHH (sonic hedgehog), WNT (wingless-type murine mammary tumor), or non-SHH/WNT subgroups.
Presentation
GAB1 antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: gab1, anti-gab1, grb2, anti-grb2, hrb2-associated-binding protein 1
Documentation
Specification Sheets
Safety Data Sheets
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Product Details
| Option | SKU | Price |
| Presentation: 3 ml Predilute | BSB-3727-3 | $217.00 |
| Presentation: 7 ml Predilute | BSB-3727-7 | $389.00 |
| Presentation: 15 ml Predilute | BSB-3727-15 | $684.00 |
| Presentation: .1 ml Concentrate | BSB-3727-01 | $226.00 |
| Presentation: .5 ml Concentrate | BSB-3727-05 | $491.00 |
| Presentation: 1 ml Concentrate | BSB-3727-1 | $779.00 |
| Presentation: Control Slides [5] | BSB-9189-CS | $101.00 |
