GATA-3 (L50-823), MMab
Price:
$144.00
SKU:
BSB 2670
Antibody type:
Mouse Monoclonal
Clone:
L50-823
Isotype:
IgG1/K
Concentrate Dilution:
1:50-1:200
Localization:
Nuclear
Tissue Control:
Breast, Skin, Placenta, Colon, Breast Carcinoma
Species Reactivity:
Human, Mouse
Sharing Discount has been applied
Description
Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
GATA-3 is a mouse monoclonal antibody for immunohistochemistry from Bio SB. Trans-acting T-cell-specific transcription factor, GATA-3 is, a protein that in humans is encoded by the GATA-3 gene. GATA-3 b regulates luminal epithelial cell differentiation in the mammary gland, is an important regulator of T cell development and plays an important role in endothelial cell biology.
GATA-3 is one of the three genes mutated in 10% of breast cancers. Nuclear expression of GATA-3 in breast cancer is considered a marker of luminal cancer in ER+ cancer and luminal androgen responsive cancer in ER-/AR+ tumors. It is highly coexpressed with FOXA1 and serves as negative predictor of basal subtype and HER-2 and is also considered a strong predictor of taxane and platin salts insensitivity.
GATA-3 expression is found in urothelial carcinoma, especially in invasive and high grade tumors. Therefore, GATA-3 can be used in a panel of antibodies for diagnosis of unknown primary carcinoma, when carcinomas of the breast or bladder are a possibility. Studies have also shown the utility of GATA-3 in differntiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine, cervix, anus and lung.
Presentation
GATA-3 antibody, clone L50-823, is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: gata3, gata-3, gata 3, anti gata3, anti gata-3, anti gata 3, anti-gata3, anti-gata-3, anti-gata 3, GATA binding protein 3, anti-GATA binding protein 3, anti GATA binding protein 3, GATA binding factor 3, trans acting T cell specific transcription factor GATA 3
Documentation
Specification Sheets
Safety Data Sheets
Ask a Question
There are currently no questions about this
product.
Product Details
| Option | SKU | Price |
| Presentation: 3 ml Predilute | BSB 2670 | $144.00 |
| Presentation: 7 ml Predilute | BSB 2671 | $289.00 |
| Presentation: 15 ml Predilute | BSB 2672 | $578.00 |
| Presentation: .1 ml Concentrate | BSB 2673 | $208.00 |
| Presentation: .5 ml Concentrate | BSB 2674 | $694.00 |
| Presentation: 1 ml Concentrate | BSB 2675 | $1,202.00 |
| Presentation: Control Slides [5] | BSB-9192-CS | $101.00 |
