Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
GATA3 is a rabbit monoclonal antibody for immunohistochemistry from Bio SB. Trans-acting T-cell-specific transcription factor, GATA-3 is, a protein that in humans is encoded by the GATA3 gene. GATA-3 b regulates luminal epithelial cell differentiation in the mammary gland, is an important regulator of T cell development and plays an important role in endothelial cell biology.
GATA3 is one of the three genes mutated in >10% of breast cancers. Nuclear expression of GATA-3 in breast cancer is considered a marker of luminal cancer in ER+ cancer and luminal androgen responsive cancer in ER-/AR+ tumors. It is highly coexpressed with FOXA1 and serves as negative predictor of basal subtype and HER-2 and is also considered a strong predictor of taxane and platin salts insensitivity.
GATA3 expression is found in urothelial carcinoma, especially in invasive and high grade tumors. Therefore, GATA3 can be used in a panel of antibodies for diagnosis of unknown primary carcinoma, when carcinomas of the breast or bladder are a possibility. Studies have also shown the utility of GATA3 in differntiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine, cervix, anus and lung.
Presentation
GATA3 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: gata3, gata-3, gata 3, anti gata3, anti gata-3, anti gata 3, anti-gata3, anti-gata-3, anti-gata 3, GATA binding protein 3, anti-GATA binding protein 3, anti GATA binding protein 3, GATA binding factor 3, trans acting T cell specific transcription factor GATA 3
