Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Sialylated protein HEG homolog 1 or Heart development protein with EGF like domains 1 (HEG1) is a novel calcium binding receptor protein involved in the Cerebral Cavernous Malformations (CCM) pathway and plays a regulatory role in heart and vessel formation by stabilizing endothelial cell junctions. HEG1 is a heavily glycosylated protein that participates in endothelial cell associations that develop the vascularsystem, and therefore plays a role in angiogenesis and the microenvironment of cellular adhesion.
The exact role of HEG1 in hepatocellular carcinoma is unclear, however,studies have shown HEG1 antibody expression indicates poor prognosis and plays important roles in hepatocellular carcinoma invasion, metastasis, and epithelial mesenchymal transition by activating Wnt/β-catenin signaling. HEG1 mucin-like membrane protein has also been found to be a sensitive andspecific biomarker for malignant mesothelioma in pleural (lung) andperitoneal (abdominal) membranes, and several other rare locations,where it supports the survival and proliferation of mesothelioma cells. HEG1 is potentially a useful prognostic biomarker and therapeutic targetfor malignant mesothelioma and hepatocellular, thyroid, and ovarian carcinomas.
HEG1 has been found to be a highly specific and sensitive marker ofepithelioid Malignant Mesothelioma and offers sensitivity comparable toconventional markers for Epithelioid Mesotheliomas, but providesconsiderably better specificity, such that the diagnosis of epithelioidmesothelioma versus NSCLC and potentially could be confirmed with acombination of HEG1 and a suitable broad spectrum carcinoma marker such as Claudin-4.
Presentation
Anti-HEG1 is a Mouse Monoclonal antibody derived from cell culturesupernatant that is concentrated, dialyzed, filter sterilized and diluted inbuffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: heg1, heg 1, heg-1, anti-heg1, anti-heg 1, anti-heg-1, Sialylated protein HEG homolog 1, Heart development protein with EGF like domains 1
