Intended Use
Analyte Specific Reagent
Summary and Explanation
Kaposi’s sarcoma-associated herpesvirus is the eighth human herpes virus; its formal name according to the International Committee on Taxonomy of Viruses is HHV-8. It causes development of cutaneous lesions such as macules, plaques, and nodules, and may invade tissues such as lymph nodes.
It is associated with Kaposi’s sarcoma (KS), primary effusion lymphoma, and multicentric Castleman's disease. HHV-8 detects the latent nuclear antigen (LNA) protein in all stages and pathological presentations of KS, which can differentiate KS from HIV-induced tumors or other neoplasia of similar morphology. Immunohistochemical detection of HHV-8 LNA is particularly useful in early detection, where inflammation but not significant tumor formation has occurred.
Presentation
HHV-8 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: hhv8, hhv-8, hhv 8, anti-hhv8, anti-hhv8, anti hhv-8, anti-hhv-8, Kaposi s sarcoma associated herpesvirus, KSHV, eighth human herpes virus