Ki-67 (EP5), RMab

Intended Use

For In Vitro Diagnostic Use

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Ki-67 is a rabbit monoclonal antibody for immunohistochemistry from Bio SB. The Ki-67 protein is a cellular marker for proliferation. It is strictly associated with cell proliferation. During the interphase, the Ki-67 antigen can be exclusively detected within the cell nucleus, whereas in mitosis most of the protein is relocated to the surface of the chromosomes. Ki-67 protein is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent from resting cells (G0).

The Ki-67 antibody is an excellent marker to determine the growth fraction of a given cell population. The fraction of Ki-67 positive tumor cells (the Ki-67 labeling index) is often correlated with the clinical course of cancer. The best-studied examples in this context are carcinomas of the prostate and the breast.