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Laminin-R (BSB-144), MMab

lamin-r, lamin r, anti-lamin-r, anti-lamin r, RPSA, anti-rpsa MAIN

Laminin-R (BSB-144), MMab

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SKU: BSB-3736-3

Antibody type: Mouse Monoclonal

Clone: BSB-144

Isotype: IgG1

Concentrate Dilution: 1:50-1:200

Localization: Cytoplasmic, Membranous

Tissue Control: Placenta, Kidney, Prostate, Tonsil

Species Reactivity: Human

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Description

Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Laminin receptor (Ribosomal Protein SA or 67LR) is a 67kDa protein in the extracellular matrix, coded by a 5,833 bp gene on Chromosome 3, containing seven exons and six introns. Laminin-R is involved in cellular adhesion to basement membranes and signal transduction pathways after binding the ligand Integrin-1. The receptor is also involved in pathways of cytoskeletal movement, chromatin structure, cellular migration, stress response, ribosomal function, translation, and rRNA processing. Laminin-R is also a receptor for green tea polyphenol and mediator in the Nitrous Oxide (eNOS) pathways used to force cancer cells into apoptosis. The 37kDa precursor protein, known also as p40, is a highly-conserved protein in the 40S ribosomal subunit.

Laminin-R antibody has been found to be overexpressed in Breast, Colorectal, Pancreatic, Prostate, and Cervical Cancer, and in Lymphomas. Laminin-R interacts with cyclin-dependent kinases and inhibitors to control G1/S, S/G2 and G2/M phase cell cycle arrest; down-regulation of the receptor is correlated with arrested cell growth and a reduction in the development of tumors. Laminin-R has also been found to be involved in regulation of Survivin expression, as well as cancer metastasis and drug resistance.

Synonyms: lamin-r, lamin r, anti-lamin-r, anti-lamin r, RPSA, anti-rpsa

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Product Details

Option	SKU	Price
Presentation: 3 ml Predilute	BSB-3736-3	$217.00
Presentation: 7 ml Predilute	BSB-3736-7	$389.00
Presentation: 15 ml Predilute	BSB-3736-15	$684.00
Presentation: .1 ml Concentrate	BSB-3736-01	$226.00
Presentation: .5 ml Concentrate	BSB-3736-05	$491.00
Presentation: 1 ml Concentrate	BSB-3736-1	$779.00
Presentation: Control Slides [5]	BSB-3736-CS	$77.05

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