Langerin (12D6), MMab

Summary and Explanation

Langerin is a type II transmembrane cell surface receptor produced by Langerhans Cells, which are immature dendritic cells of the epidermis and mucosa. Epidermal LCs possess strong immunohistochemistry capacity and play a central role in the initiation and regulation of immune responses. Langerin is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and provides access to a nonclassical antigen-processing pathway.

Human spleen, lymph node, thymus, liver, lung, and heart express langerin antibody. Langerin antibody expression has utility in differentiating Langerhans cell histiocytosis from other non- Langerhans cell histiocytic proliferations.