Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Maspin (mammary serine protease inhibitor) is a protein that in humans is encoded by the SERPINB5 gene. This protein belongs to the serpin (serine protease inhibitor) superfamily. SERPINB5 was originally reported to function as a tumor suppressor gene in epithelial cells, suppressing the ability of cancer cells to invade and metastasize to other tissues.
Maspin has been shown in primary breast cancer to be regulated by wild-type p53, defining a new category of molecular targets of p53 that have the potential to negatively regulate tumor invasion and metastasis. Loss of Maspin antibody expression correlates with increased tumor aggressiveness and poor prognosis in advanced breast and prostate cancer. In contrast, Maspin antibody has been shown to be overexpressed in pancreatic, ovarian, thyroid, gastric, lung, bladder, breast, skin and colon cancer. Several studies have investigated the prognostic significance of Maspin expression in lung cancer. In primary non-small cell lung cancer (NSCLC) was an independent negative prognostic factor for overall survival, whereas strong nuclear Maspin expression was associated with increased overall and disease-free survival in patients with resectable NSCLC.
Presentation
Maspin antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: Maspin, Peptidase inhibitor 5, PI 5, PI5, protease inhibitor 5 maspin, serine or cysteine proteinase inhibitor clade B ovalbumin member 5, Serpin B5, serpin peptidase inhibitor clade B ovalbumin member 5, anti-maspin
