Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
MCM-2 (mini-chromosome maintenance 2) is a human gene. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that is involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex, and may be involved in the formation of replication forks and in the recruitment of other DNA replication-related proteins. This protein forms a complex with MCM-4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by protein kinases CDC2 and CDC7.
MCM-2 is essential for eukaryotic DNA replication and drives the formation of pre-replicative complexes, which is the key first step during the G1 phase. Therefore, altered MCM-2 antibody expression may be a hallmark of cell-cycle deregulation, which could be the most essential mechanism in the development and progression of human cancers. MCM2 has been identified by DNA microarray and transcriptional profiling as a gene that is over-expressed in Cervical Carcinomas. This protein is over-expressed in Cervical Dysplasia as a result of HPV infection. The over-expression of MCM-2 provides the link between oncogenic HPV infection and the molecular event of Cervical Dysplasia.
Presentation
MCM2 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: anti-MCM2, anti MCM2, anti-mcm-2, anti mcm-2, anti-mcm 2, anti mcm 2, BM28, CCNL1, cdc19, CDCL1, cell devision cycle like 1, cyclin like 1, D3S3194, DNA replication licensing factor MCM2, KIAA0030, MCM2 minichromosome maintenance deficient 2 mitotin, MGC10606, minichromosome maintenance complex component 2, minichromosome maintenance deficient 2 mitotin, minichromosome maintenance protein 2 homolog, MITOTIN, Nuclear protein BM28
