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MNDA (BSB-157), MMab

MNDA, anti-mnda, Myeloid cell Nuclear Differentiation Antigen, anti-Myeloid cell Nuclear Differentiation Antigen MAIN

MNDA (BSB-157), MMab

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Price: $217.00

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SKU: BSB-3738-3

Antibody type: Mouse Monoclonal

Clone: BSB-157

Isotype: IgG1

Concentrate Dilution: 1:50-1:200

Localization: Nuclear

Tissue Control: Breast, Colon, Falopian Tube, Brain

Species Reactivity: Human

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Description

Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Myeloid cell Nuclear Differentiation Antigen (MNDA) is present in granulocytes and monocytes (myeloid and B cells), found in the marginal zones of germinal centers in tonsil, lymph node, spleen. MNDA is a highly basic protein from 1q22, and is part of the family of nuclear proteins expressed in reaction to interferons. MNDA contains a Pyrin ‘death domain’ used in self-association and is suggested to induce or help prevent different programmed cell death pathways in hematopoietic cells.

MNDA antibody expression is studied mainly in leukemias and lymphomas. MNDA antibody is a marker to distinguish Nodal Marginal Zone Lymphoma from Follicular Lymphoma, and has been shown to be downregulated in Myelodysplastic Syndrome, a precursor for Leukemia. MNDA overexpression in Osteosarcoma induces apoptosis and protects patients from metastasis, and expression in Chronic Lymphocytic Leukemia indicates the degradation of anti-apoptotic mRNA, allowing cells suffering genotoxic stress to undergo apoptosis.

Synonyms: MNDA, anti-mnda, Myeloid cell Nuclear Differentiation Antigen, anti-Myeloid cell Nuclear Differentiation Antigen

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Product Details

Option	SKU	Price
Presentation: 3 ml Predilute	BSB-3738-3	$217.00
Presentation: 7 ml Predilute	BSB-3738-7	$389.00
Presentation: 15 ml Predilute	BSB-3738-15	$684.00
Presentation: .1 ml Concentrate	BSB-3738-01	$226.00
Presentation: .5 ml Concentrate	BSB-3738-05	$491.00
Presentation: 1 ml Concentrate	BSB-3738-1	$779.00
Presentation: Control Slides [5]	BSB-3738-CS	$77.05

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MNDA (BSB-157), MMab

MNDA (BSB-157), MMab

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