MSH2 (BSB-147), MMab
Price:
$162.00
SKU:
BSB-3722-3
Antibody type:
Mouse Monoclonal
Clone:
BSB-147
Isotype:
IgG1
Concentrate Dilution:
1:100-1:500
Localization:
Nuclear
Tissue Control:
Colon, Skin, Breast, Tonsil
Species Reactivity:
Human
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Description
Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
MSH2 is a mouse monoclonal antibody for immunohistochemistry from Bio SB. MSH2 is a mismatch repair gene commonly associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC). This gene was identified as a locus frequently mutated in HNPCC. When cloned, it is a human homolog of the E. coli DNA mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC.
MSH2 is abnormally deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition found in Hereditary Non-Polyposis Colon Cancer. This MSH2 antibody (along with MLH1 antibody) is useful in screening patients and families for this rare condition. Colon cancers that are microsatellite unstable have a better prognosis than their microsatellite stable counterparts.
Presentation
MSH2 antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: COCA1, DNA mismatch repair protein Msh2, FCC1, hMSH2, HNPCC, HNPCC1, homolog 2 colon cancer nonpolyposis type 1 E coli, MutS protein homolog 2, msh-2, anti-msh2, anti-msh-2, anti-msh-2, anti msh2, anti msh-2, anti msh 2
Documentation
Specification Sheets
Safety Data Sheets
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Product Details
| Option | SKU | Price |
| Presentation: 3 ml Predilute | BSB-3722-3 | $162.00 |
| Presentation: 7 ml Predilute | BSB-3722-7 | $293.00 |
| Presentation: 15 ml Predilute | BSB-3722-15 | $530.00 |
| Presentation: .1 ml Concentrate | BSB-3722-01 | $198.00 |
| Presentation: .5 ml Concentrate | BSB-3722-05 | $484.00 |
| Presentation: 1 ml Concentrate | BSB-3722-1 | $788.00 |
| Presentation: Control Slides [5] | BSB-9284-CS | $101.00 |
