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MSH2 (RBT-MSH2), RMab

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Price: $329.00

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SKU: BSB 6926

Antibody type: Rabbit Monoclonal

Clone: RBT-MSH2

Isotype: IgG

Concentrate Dilution: 1:50-1:200

Localization: Nuclear

Tissue Control: Colon, Skin, Breast, Tonsil

Species Reactivity: Human

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Description

Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

MSH2 is a rabbit monoclonal antibody for immunohistochemistry from Bio SB. MSH2 is a mismatch repair gene commonly associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC). This gene was identified as a locus frequently mutated in HNPCC. When cloned, it is a human homolog of the E. coli DNA mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC.

MSH2 is abnormally deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition found in Hereditary Non-Polyposis Colon Cancer. This anti-MSH2 antibody (along with MLH1 antibody) is useful in screening patients and families for this rare condition. Colon cancers that are microsatellite unstable have a better prognosis than their microsatellite stable counterparts.

Presentation

MSH2 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Synonyms: COCA1, DNA mismatch repair protein Msh2, FCC1, hMSH2, HNPCC, HNPCC1, homolog 2 colon cancer nonpolyposis type 1 E coli, MutS protein homolog 2, msh-2, anti-msh2, anti-msh-2, anti-msh-2, anti msh2, anti msh-2, anti msh 2

Documentation

Specification Sheets

IVD - CE

Safety Data Sheets

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Product Details

Option	SKU	Price
Presentation: 3 ml Predilute	BSB 6926	$329.00
Presentation: 7 ml Predilute	BSB 6927	$598.00
Presentation: 15 ml Predilute	BSB 6928	$955.00
Presentation: .1 ml Concentrate	BSB 6929	$233.00
Presentation: .5 ml Concentrate	BSB 6930	$523.00
Presentation: 1 ml Concentrate	BSB 6931	$973.00
Presentation: Control Slides [5]	BSB-9284-CS	$101.00

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