MUC2 (EP187), RMab

Summary and Explanation

Mucin 2, also known as MUC2, is a human gene that encodes a member of the mucin protein family. The protein encoded by this gene forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains.

MUC2 antibody expression is detected in such human tissues as normal colon, breast, prostate, salivary gland, and in gastrointestinal, colonic, breast and prostate neoplasia. This antibody labels MUC2 in normal Colon and Colon Carcinomas where it produces intense perinuclear staining in goblet cells. It also reacts with normal and neoplastic breast tissues and with Prostate Adenocarcinoma.