Myeloperoxidase (Polyclonal), RPab

Summary and Explanation

Myeloperoxidase (MPO) is a peroxidase enzyme most abundantly present in neutrophil granulocytes. It is a lysosomal protein stored in azurophilic granules of the neutrophil. MPO has a heme pigment, which causes its green color in secretions rich in neutrophils, such as pus and some forms of mucus. Historically, immunohistochemical staining for myeloperoxidase was used in the diagnosis of Acute Myeloid Leukemia to demonstrate that the leukemic cells were derived from the myeloid lineage. Myeloperoxidase staining is still important in the diagnosis of Extramedullary Leukemia or Chloroma.

Myeloperoxidase antibody detects granulocytes and monocytes in blood and precursors of granulocytes in the bone marrow. This antibody can detect myeloid cell populations of the bone marrow as well as in other sites.