Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
MyoD1 belongs to a family of proteins known as myogenic regulatory factors (MRFs) and has a key role in regulating muscle differentation. These bHLH (basic helix loop helix) transcription factors act sequentially in myogenic differentiation. MyoD1 antibody is expressed in activated satellite cells, but not in quiescent satellite cells. In development, MyoD1 commits mesoderm cells to a skeletal lineage, and then regulates that process. It may also play a role in muscle repair.
In abnormal tissues, MyoD1 antibody labels tumor cells in Rhabdomyosarcoma and is one of the earliest markers of myogenic commitment.
Presentation
MyoD1 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: MYOD1, anti-MyoD, anti MyoD, anti-MYOD1, anti MYOD1, myogenic differentiation 1, MYF3, MYOD, PUM, bHLHc1