Myoglobin (EP87), RMab

Summary and Explanation

Myoglobin is a single-chain globular protein of 153 amino acids, containing a heme (iron-containing porphyrin) prosthetic group in the center around which the remaining apoprotein folds. With a molecular weight of 16.7 kDa, Myoglobin is the primary oxygen-carrying pigment of muscle tissues.

Immunostaining with Myoglobin antibody provides a specific, sensitive and practical procedure for the identification of Rhabdomyosarcoma. Since myoglobin is found exclusively in skeletal and cardiac muscle, it may be used to distinguish Rhabdomyosarcoma from other soft-tissue tumors. Myoglobin antibody staining is also useful when demonstrating rhabdomyoblastic differentiation in other tumors, e.g., Neurogenic Sarcomas and Malignant Mixed Mesodermal Tumors of the uterus and ovary.