Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Neurofilaments are the Type IV family of intermediate filaments that are found in high concentrations along the axons of vertebrate neurons.
Neurofilament antibody identifies an antigen localized in a number of neural, neuroendocrine and endocrine tumors. Neuromas, Ganglioneuromas, Gangliogliomas, Ganglioneuroblastomas and Neuroblastomas stain positively for neurofilament. Neurofilaments are also present in Paragangliomas and Adrenal and Extra-Adrenal Pheochromocytomas. Carcinoids, Neuroendocrine Carcinomas of the Skin, and Oat Cell Carcinomas of the Lung also express neurofilament.
Presentation
Neurofilament antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: NEFL, NF L, NFL, 68 kDa neurofilament protein, CMT1F, CMT2E, FLJ53642, light molecular weight neurofilament protein, Neurofilament light polypeptide, neurofilament protein light chain, neurofilament subunit NF L, Neurofilament triplet L protein, neurofilament light polypeptide 68kDa, NF68, anti-neurofilament, anti neurofilament, anti-nelf, anti-nfl