p21 (DCS-60.2), MMab
Price:
$140.00
SKU:
BSB 2063
Antibody type:
Mouse Monoclonal
Clone:
DCS-60.2
Isotype:
IgG2a
Concentrate Dilution:
1:50-1:200
Localization:
Cytoplasmic, Nuclear
Tissue Control:
Tonsil, Colon, Fallopian Tube, Breast Cancer
Species Reactivity:
Human
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Description
Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
p21 is a potent cyclin-dependent kinase inhibitor. The p21 protein binds to and inhibits the activity of cyclin-CDK2 or -CDK1 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a varity of stimuli. In addition to growth arrest, p21 can mediate cellular senescence. p21 can also interact with proliferating cell nuclear antigen (PCNA) and plays a regulatory role in S phase DNA replication and DNA damage repair.
Normal cells typically display a rather intense nuclear p21 antibody expression. Loss of p21 expression has been associated with poor prognosis in several carcinomas including Gastric Carcinoma, Non-Small Cell Lung Carcinoma and Thyroid Carcinoma.
Presentation
p21 antibody is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: Cdkn1a, CIP1, Waf1, anti-p21, anti p21, anti CDKN1A, anti CIP1, anti WAF1, anti-CDKN1A, anti-CIP1, anti-WAF1, CAP20, CDKI, Cdkn1, cyclin dependent kinase inhibitor 1, cyclin dependent kinase inhibitor 1A P21, mda6, Melanoma differentiation associated protein, P21, p21 WAF1 CIP1, p21Cip1, p21WAF, SDI1
Documentation
Specification Sheets
Safety Data Sheets
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Product Details
| Option | SKU | Price |
| Presentation: 3 ml Predilute | BSB 2063 | $140.00 |
| Presentation: 7 ml Predilute | BSB 2064 | $261.00 |
| Presentation: 15 ml Predilute | BSB 2065 | $471.00 |
| Presentation: .1 ml Concentrate | BSB 2066 | $152.00 |
| Presentation: .5 ml Concentrate | BSB 2067 | $368.00 |
| Presentation: 1 ml Concentrate | BSB 2068 | $567.00 |
| Presentation: Control Slides [5] | BSB 2069 | $77.05 |
