Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
PAX-8 is a rabbit monoclonal antibody for immunohistochemistry from Bio SB. The PAX-8 antibody is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. The PAX-8 antibody is also expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. Studies have also found PAX-8 antibody expression in renal tubules as well as renal carcinoma, nephroblastoma and seminoma. Normal lung and lung carcinomas do not express PAX-8. Similarly, the absence of expression of PAX-8 in breast and other non-GYN carcinomas other than those primary to the thyroid indicates that the PAX-8 antibody is an important new marker of ovarian cancer and a useful marker for the differential diagnoses in lung and neck tumors, or tumors at distant sites where primary lung carcinoma or thyroid carcinoma are possibilities.
The PAX-8 antibody, combined with organ system-specific markers such as uroplakin, mammaglobin, and TTF-1 can be a very useful panel to determine the primary site of invasive micropapillary carcinomas of ovary from bladder, lung, and breast.
Presentation
PAX-8 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: pax8, pax-8, pax 8, anti pax8, anti pax-8, anti pax 8, anti-pax8, anti-pax-8, anti-pax 8, paired box 8, Paired box protein Pax 8, paired domain gene 8
