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PDGFR-B (RBT-PDGFRB), RMab

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Price: $331.00

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SKU: BSB 2349

Antibody type: Rabbit Monoclonal

Clone: RBT-PDGFRB

Isotype: IgG

Concentrate Dilution: 1:10-1:50

Localization: Cytoplasmic

Tissue Control: Placenta, Breast, Kidney, Cervix

Species Reactivity: Human, Mouse, Rat

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Description

Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Beta-type Platelet-Derived Growth Factor Receptor is a protein that in humans is encoded by the PDGFRB gene. This gene encodes a cell surface tyrosine kinase receptor for members of the Platelet-Derived Growth Factor family (PDGF), which is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB.

The PDGFR-B antibody detects translocation of the PDGFR gene with the Tel gene, which is linked to Chronic Myelomonocytic Leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

Presentation

PDGFR-B antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

Synonyms: CD140B, PDGFR, PDGFRB, sc374573, PDGFR-β, PDGFR-beta, PDGFR-b, PDGFR b, PDGFR β, PDGFRβ, anti CD140B, anti PDGFR, anti PDGFR β, anti PDGFR-β, anti PDGFRB, anti PDGFRβ, anti-CD140B, anti-PDGFR, anti-PDGFR β, anti-PDGFR-β, anti-PDGFRB, anti-PDGFRβ, Beta platelet derived growth factor receptor, Beta type platelet derived growth factor receptor, CD140 antigen like family member B, JTK12, PDGF R beta, PDGFR 1, PDGFR beta, PDGFR1, platelet derived growth factor receptor 1, platelet derived growth factor receptor beta, platelet derived growth factor receptor beta polypeptide, pdgfrb, anti-pdgfrb, anti-pdgfr-b, anti pdgfr-b, anti pdgfrb

Documentation

Specification Sheets

IVD - CE

Safety Data Sheets

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Product Details

Option	SKU	Price
Presentation: 3 ml Predilute	BSB 2349	$331.00
Presentation: 7 ml Predilute	BSB 2350	$603.00
Presentation: 15 ml Predilute	BSB 2351	$1,081.00
Presentation: .1 ml Concentrate	BSB 2352	$363.00
Presentation: .5 ml Concentrate	BSB 2353	$977.00
Presentation: 1 ml Concentrate	BSB 2354	$1,477.00
Presentation: Control Slides [5]	BSB 2355	$77.05

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