Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Placental Alkaline Phosphatase (PLAP) is found in trophoblast cells of normal mature human placenta, Seminomas of testis and Ovarian Carcinomas. Detection of alkaline phosphatase in serum is a marker for Ovarian and Testicular Cancer. This antibody reacts with a membrane-bound isoenzyme of placental alkaline phosphatase occurring in the placenta during the 3rd trimester of gestation.
PLAP antibody immunoreacts with Germ Cell Tumors and can discriminate between these and other neoplasms. Somatic neoplasms (e.g., breast, gastrointestinal, prostatic and urinary cancers) may also immunoreact with antibodies to PLAP. PLAP antibody positivity, in conjunction with keratin negativity, favors Seminoma over Carcinoma. Germ Cell Tumors are usually keratin positive but they regularly fail to stain with EMA, whereas most Carcinomas stain with anti-EMA. This antibody has shown cross-reaction with human intestinal alkaline phosphatase.
Presentation
PLAP antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: anti-PLAP, anti PLAP, anti-ALPP, anti ALPP, placental alkaline phosphatase, anti-placental alkaline phosphatase, anti placental alkaline phosphatase, alkaline phosphatase Regan isozyme, alkaline phosphatase placental type, alkaline phosphomonoesterase, ALP, FLJ61142, glycerophosphatase, PALP, PLAP, PLAP 1, placental alkaline phosphatase 1, alkaline phosphatase placental, Regan isozyme
