Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
PU.1 is a member of the Ets family of transcription factors and is required for the development of multiple hematopoietic lineages. It plays a pivotal role in normal myeloid differentiation and regulates the expression of immunoglobulin and other genes that are important for B-cell development. It is expressed in the myeloid lineage and in immature as well as mature B lymphocytes, with the exception of plasma cells.
PU.1 antibody is expressed in germinal center B-cells and mantle B-cells. The antibody is positive in various lymphomas including B-Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma, Marginal Zone Lymphoma, Burkitt Lymphoma, Diffuse Large Cell Lymphoma, Diffuse Large B-cell Lymphoma, T-cell rich B-cell Lymphoma, Nodular Lymphocyte Predominant Hodgkin Lymphoma. It has been demonstrated that a high level of expression of GC antigens (including PU.1) has a positive association with longer overall survival and progression free survival in the case of Follicular Lymphoma.
Presentation
PU.1 antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: SPI1, anti-PU.1, anti PU.1, anti-SPI1, anti SPI1, Spi-1 proto-oncogene, anti-Spi-1 proto-oncogene, anti Spi-1 proto-oncogene, spleen focus forming virus SFFV proviral integration oncogene spi1, OF, PU 1, SFPI1, SPI 1, SPI A
