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SS18-SSX (RBT-SS18-SSX), RMab

ss18-ssx, anti-ss19-ssx, anti ss18-ssx, SSX1, Protein SSX1, Protein SSX8, Protein SSX9, SSRC, SSX MAIN

SS18-SSX (RBT-SS18-SSX), RMab

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Price: $225.00

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SKU: BSB-3796-3

Antibody type: Rabbit Monoclonal

Clone: RBT-SS18-SSX

Isotype: IgG

Concentrate Dilution: 1:50-1:200

Localization: Nuclear

Tissue Control: Synovial Sarcoma with the SS18-SSX fusion

Species Reactivity: Human

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Description

Intended Use

For In Vitro Diagnostic Use

Summary and Explanation

Expression of SS18-SSX fusion protein is the hallmark of Synovial Sarcoma, a type of soft tissue sarcoma that accounts for 5-10% of all soft tissue sarcoma. Diagnosis of synovial sarcoma can be challenging due to histologic overlap with a range of other tumors, therefore, IHC is routinely used in differential diagnosis. SS18-SSX is a fusion oncoprotein created during chromosome translocation in which the SS18 gene on chromosome 18 is fused to the SSX1, SSX2, or SSX4 gene on the X chromosome.

Normally, SS18 subunit and BAF47 subunit bind to BAF (mSWI/SNF) complex which produces polycomb-mediated repression of Sox-2 and cessation of proliferation. SS18-SSX renders the BAF chromatin remodeling complex aberrant through the addition of SSX to the SS18 subunit and the loss of BAF47 subunit from the BAF (mSWI/SNF) complex. The altered complexes reverse the polycomb-mediated repression and result in the activation of Sox-2 and uncontrolled proliferation.

Synonyms: ss18-ssx, anti-ss19-ssx, anti ss18-ssx, SSX1, Protein SSX1, Protein SSX8, Protein SSX9, SSRC, SSX

Documentation

Specification Sheets

IVD - CE

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Product Details

Option	SKU	Price
Presentation: 3 ml Predilute	BSB-3796-3	$225.00
Presentation: 7 ml Predilute	BSB-3796-7	$337.00
Presentation: 15 ml Predilute	BSB-3796-15	$564.00
Presentation: .1 ml Concentrate	BSB-3796-01	$225.00
Presentation: .5 ml Concentrate	BSB-3796-05	$481.00
Presentation: 1 ml Concentrate	BSB-3796-1	$819.00
Presentation: Control Slides [5]	BSB-9434-CS	$101.00

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