Intended Use
For In Vitro Diagnostic Use
Summary and Explanation
Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. The survivin antibody is expressed highly in most human tumors and fetal tissue, but is completely absent in terminally differentiated cells. Survivin expression is also highly regulated by the cell cycle and is only expressed in the G2-M phase. It is known that survivin localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis.
The association of survivin antibody expression with tumor progression, but not overall patient survival, has been observed in a variety of malignancies including renal cell carcinoma, ovary carcinoma, hepatocellular carcinoma, prostate carcinoma and breast carcinoma.
Presentation
Survivin antibody is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Synonyms: BIRC5, baculoviral IAP repeat containing 5, anti baculoviral IAP repeat containing 5, anti BIRC5, anti survivin, anti-baculoviral IAP repeat containing 5, anti-BIRC5, anti-survivin, API4, Apoptosis inhibitor 4, apoptosis inhibitor survivin, Baculoviral IAP repeat containing protein 5, EPR 1, survivin variant 3 alpha
